Vliv perzistentních organických polutantů na mitochondriální funkce a vznik metabolického syndromu
Klíčová slova:
perzistentní organické polutanty, mitochondrie, diabetes mellitus, obezita, metabolický syndromAbstrakt
Persistent organic pollutants are bioaccumulative and toxic to living organisms. Persistent substances may increase oxidative stress and start inflammatory processes, which are the major factors in the pathogenesis of obesity-related diseases. A clear link was found between mitochondrial dysfunction and the type 2 diabetes mellitus. A mutation in mitochondrial DNA β-cells of pancreas leads to the worsening of insulin secretion, cell apoptosis and subsequent reduction of β-cells.